Rhodium-catalyzed arylative cyclization of alkynones induced by addition of arylboronic acids |
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Authors: | Tomoya Miura |
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Affiliation: | Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan |
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Abstract: | Alkynones react with arylboronic acids in the presence of a rhodium(I) catalyst to afford four- and five-membered-ring cyclic alcohols equipped with a tetrasubstituted exocyclic olefin. The cyclic allylic alcohol skeleton is constructed by the carbon-carbon bond formation between the carbonyl group and an alkenylrhodium(I) intermediate formed by the regioselective addition of an arylrhodium(I) species across the carbon-carbon triple bond. |
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Keywords: | Rhodium Boron Addition Cyclization Alkynone |
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