Classical carbonyl reactivity enables a short synthesis of the core structure of acutumine |
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| Authors: | Robert J. Moreau |
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| Affiliation: | Frick Chemical Laboratory, Princeton University, Princeton, NJ 08544-1009, United States |
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| Abstract: | The development of a direct synthesis of the complex core topology of the alkaloid acutumine from a simple keto proline derivative is described. An efficient sequence of three carbonyl-dependent reactions is at the heart of this design for synthesis. |
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| Keywords: | Acutumine The carbonyl group β-Elimination Michael reaction Dieckmann condensation Chlorine-containing alkaloids |
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