Efficient synthesis of cephalotaxine- and deoxyharringtonine analogues by a trimethylaluminium-mediated domino reaction |
| |
| Authors: | Lutz F Tietze Holger Braun Serry AA El Bialy |
| |
| Institution: | a Institut für Organische Chemie und Biomolekulare Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany
b Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt |
| |
| Abstract: | The synthesis of cephalotaxine- and cephalotaxine amide analogues 14a-c and 16a-c as well as of the deoxyharringtonine analogues 5a,b was performed employing a trimethylaluminium-mediated domino reaction of 9a-c and 8 to give the spirocyclic compounds 7a-c, which was followed by a palladium catalyzed α-arylation. |
| |
| Keywords: | Alkaloids Cephalotaxine Domino reactions Harringtonines Palladium Spiro compounds |
| 本文献已被 ScienceDirect 等数据库收录！ |
