Three-component coupling using arynes and isocyanides: straightforward access to benzo-annulated nitrogen or oxygen heterocycles |
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| Authors: | Hiroto Yoshida |
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| Institution: | Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan |
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| Abstract: | A variety of aldehydes, ketones, benzoquinones, or sulfonylimines were found to couple with arynes and isocyanides, giving iminodihydroisobenzofuran or iminoisoindoline derivatives of structural diversity in a straightforward manner. Nucleophilic addition of isocyanides to arynes, a first step of the three-component coupling, was proved to be reversible by the reaction of an unsymmetrical aryne. |
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| Keywords: | Aryne Isocyanide Nitrogen heterocycle Oxygen heterocycle Three-component coupling |
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