Development of new methods toward efficient immobilization of chiral catalysts |
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Authors: | Shinobu Takizawa |
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Institution: | The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan |
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Abstract: | BINOL moieties are efficiently immobilized onto the surface of a micelle-derived spherical polymer and a monolayer-protected Au cluster (Au-MPC). Ti-BINOLate complexes generated from the BINOL immobilized polymer and Au-MPC are found to promote catalytic asymmetric alkylation of benzaldehyde with Et2Zn to afford the adduct in up to 84% ee and 86% ee, respectively. Au-MPC-supported multicomponent asymmetric catalyst was prepared and used in the Michael reaction of 2-cyclohexen-1-one with dibenzyl malonate affording the adduct in up to 67% yield and 98% ee. |
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Keywords: | Micelle-derived polymer Immobilization MPC Enantioselective reactions |
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