Drug loaded poly[Lac(Glc-Leu)] microparticles: Formulation and release characteristics |
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| Authors: | Sagar M Agnihotri Pradeep R Vavia |
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| Institution: | aPharmaceutical Division, Institute of Chemical Technology, University of Mumbai, Nathalal Parikh Street, Matunga, Mumbai 400019, India |
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| Abstract: | Valdecoxib has been entrapped in sub-5 μm particles of polyLac(Glc-Leu)] copolymer using a oil-in-water (o/w) emulsification–solvent evaporation technique. To achieve monodispersed sized particles, a microfluidizer was used as ultrasonication device. Formulation parameters such as effect of polymer load, ultrasonication time, stabilizer concentration and stirring rate have a profound effect on particle size, and polydispersity. By adjustment of these parameters, microparticles ranging from about 0.8 to more than 4 μm have been prepared. |
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| Keywords: | Poly[Lac(Glc-Leu)] Valdecoxib Formulation parameters |
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