Light, Reactive Oxygen Species, and Magnetic Fields Activating ERK/MAPK Signaling Pathway in Cultured Zebrafish Cells |
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Authors: | Yoshimi Uchida Tadanori Shimomura Jun Hirayama Hiroshi Nishina |
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Institution: | (1) Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; |
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Abstract: | To guarantee that organism’s biological rhythms remain tied to the rhythms of its environment, the circadian clock must be
able to reset itself in response to environmental cues. The main environmental stimulus for organisms is light, which is provided
by day–night cycles. Cultured lines of zebrafish cells have been established as an attractive vertebrate cell-based model
suitable for the examination of the light signaling pathway for entraining the circadian clock. Studies using these cell lines
have revealed critical roles for the mitogen-activated protein kinase (MAPK) signaling pathways in light-dependent circadian
entrainment. Here, we show in cultured zebrafish cells that artificial magnetic fields induce extracellular signal-regulated
kinase (ERK)/MAPK activation with kinetics analogous to those elicited by light, suggesting that magnetic fields may influence
circadian regulation in zebrafish. Our findings indicate that cultured zebrafish cells represent a valuable system for investigating
the links between magnetic fields and the signaling pathways responsible for the synchronization of vertebrate circadian clocks
under laboratory conditions. |
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Keywords: | |
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