| 侧链含羟基聚(D,L-丙交酯-co-碳酸酯)的合成与表征 |
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| 引用本文： | 毛静,郭颖志,夏宇正,顾忠伟. 侧链含羟基聚(D,L-丙交酯-co-碳酸酯)的合成与表征[J]. 高分子学报, 2006, 0(9): 1121-1124 |
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| 作者姓名： | 毛静 郭颖志 夏宇正 顾忠伟 |
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| 作者单位： | 北京化工大学材料科学与工程学院,北京,100029;国家人口计生委,科学技术研究所,北京,100081;国家生物医学材料工程技术研究中心(四川大学)成都,610064 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);国家自然科学基金 |
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| 摘 要： | 聚乳酸(PLA)具有良好的生物相容性及可生物降解性,是适用于组织工程及药物释放系统的聚酯材料,一直是生物医用材料领域中研究的热点之一[1,2].但由于这类聚酯材料是疏水性的,因而存在多肽、蛋白质药物包覆量太低,控释系统制备过程及存放过程中易于失活及药物释放过程难于控制等
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| 关 键 词： | 聚(D L-丙交酯-co-碳酸酯) 功能化 生物材料 |
| 收稿时间： | 2005-05-15 |
| 修稿时间： | 2005-05-24 |
SYNTHESIS AND CHARACTERIZATION OF POLY(D,L-LACTIDE-co-CYCLICCARBONATE)S WITH HYDROXYL PENDANT FUNCTIONAL GROUPS |
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| MAO Jing,GUO Yingzhi,XIA Yuzheng,GU Zhongwei. SYNTHESIS AND CHARACTERIZATION OF POLY(D,L-LACTIDE-co-CYCLICCARBONATE)S WITH HYDROXYL PENDANT FUNCTIONAL GROUPS[J]. Acta Polymerica Sinica, 2006, 0(9): 1121-1124 |
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| Authors: | MAO Jing GUO Yingzhi XIA Yuzheng GU Zhongwei |
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| Affiliation: | 1 Bering University of Chendcal Technology, Bering 100029;2 National Research Institute for Family Planning, Belting 100081 ;3 National Engineering Research Center for Biomaterials, Chengdu 610064 |
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| Abstract: | A six-member cyclic carbonate with protected functional groups was synthesized from tetramethylolmethane,benzaldehyde and ethyl choroformate.Coplymerization of(D,L-lactide) with cyclic carbonate was carried out through conventional ring-opening polymerization using Sn(Oct)_2 as the catalyst.The effects of different catalysts,polymerization time and monomer-to-catalyst molar ratio on the molecular weight were investigated.The methods of removing protected groups were studied.Results showed the protected groups were effectively removed via catalytic hydrogenation.(Poly(D,L-lactide-co-cycliccarbonate)s) with hydroxyl pendant functional groups was obtained. |
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| Keywords: | Poly(D L-lactide-co-cyclic carbonate)s Functionalization Biomaterials |
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