| 新型含1,2,4-三唑基的1,5-苯并硫氮杂的合成和表征 |
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| 引用本文： | 杨德保,刘方明,沈松伟,陈盛钦.新型含1,2,4-三唑基的1,5-苯并硫氮杂的合成和表征[J].有机化学,2010,30(2):244-249. |
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| 作者姓名： | 杨德保 刘方明 沈松伟 陈盛钦 |
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| 作者单位： | 杭州师范大学材料与化学化工学院,杭州,310036 |
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| 摘 要： | 以α-溴代苯乙酮为原料,在三乙胺作用下制备α-(1,2,4-三唑-1-基)-芳基乙酮(1a～1c),再与芳香醛发生羟醛缩合反应制备相应的含三唑基的查尔酮2a～2l,将中间体2a～2l同邻氨基硫酚合成新型的2,4-二芳基-3-(1,2,4-三唑-1-基)-2,3-二氢-1,5-苯并硫氮杂(3a～3l).所得化合物的结构经元素分析,IR,MS和1HNMR确认,同时用X射线衍射法测定了化合物2a和3a的晶体结构.
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| 关 键 词： | 查尔酮 1 2 4-三唑 1 5-苯并硫氮杂 晶体结构 |
| 收稿时间： | 2008-11-21 |
| 修稿时间： | 2009-01-03 |
Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1 ,5-benzo[b]thiazepine Derivatives |
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| Yang Debao,Liu Fangming,Shen Songwei,Chen Shengqin.Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1 ,5-benzo[b]thiazepine Derivatives[J].Chinese Journal of Organic Chemistry,2010,30(2):244-249. |
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| Authors: | Yang Debao Liu Fangming Shen Songwei Chen Shengqin |
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| Institution: | (College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036) |
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| Abstract: | The chalcones 2a～2l were synthesized by aldol condensation reaction of arylaldehydes with 1-aryl-2-(1H-1,2,4-triazol-1-y1)ethanones (1a～1c), which were prepared from 2-bromo-1-arylethanones. Then the intermediates 2a～2l were reacted with 2-aminobenzenethiol to give a series of 3-(1,2,4-triazol-1-y1)-1,5-benzob]thiazepine derivatives 3a～31. Compounds 3a～3l were confirmed by means of elemental analysis, IR,~1H NMR, MS techniques, and compounds 2a and 3a were analyzed by X-ray single-crystal diffraction. |
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| Keywords: | chalcone 1 2 4-triazole 1 5-benzo[b]thiazepine crystal structure |
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