A comparative study using conventional methods,ionic liquids,microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacetyl-1,2,3,4-tetrahydropyridines |
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Authors: | Valquiria P Andrade Mateus Mittersteiner Márcio M Lobo Clarissa P Frizzo Hélio G Bonacorso Marcos AP Martins Nilo Zanatta |
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Institution: | Núcleo de Química de Heterociclos (NUQUIMHE), Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil |
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Abstract: | This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2-arylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines. In all of the reactions tested, the products were obtained at very good yields (87–97%), but the reaction times were very different, depending on the method used. Comparing to other methods, the time decreased to 1?min when BMIM]BF4 under MW irradiation was used, thus evidencing a synergic effect. |
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Keywords: | Heterocycles Tetrahydropyridin-2-arylamines Ionic liquids Microwave irradiation |
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