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Oxidative radical phosphonotrifluoromethylthiolation of unactivated alkenes with alkyl phosphonate,silver(I) trifluoromethanethiolate and potassium persulfate |
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| Authors: | Zhiwei Xiao Yongan Liu Liping Zheng Xiumiao Zhou Youzhuan Xie Chao Liu Yong Guo Qing-Yun Chen |
| Institution: | 1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China;2. School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, 18 Yingcai Street, Zhengzhou, 450044, China;3. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 20001, China |
| Abstract: | We report herein a mild and efficient oxidative radical intermolecular phosphonotrifluoromethylthiolation of unactivated alkenes with good functional group tolerance. The reaction operates via a radical pathway involving oxidative generation of phosphonyl radicals and umpolung radical coupling of silver trifluoromethanethiolate. |
| Keywords: | Phosphonotrifluoromethylthiolation Alkene Radical Oxidation |
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