Enantioselective anti-Mannich reaction catalyzed by modularly designed organocatalysts |
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Authors: | Swapna Konda John C-G Zhao |
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Institution: | Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-0698, USA |
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Abstract: | A highly stereoselective method for achieving the anti-Mannich reaction of aldehydes and ketones with ethyl (4-methoxyphenylimino)acetate was realized using the modularly designed organocatalysts (MDOs) self-assembled from cinchona alkaloid derivatives and (R)-pyrrolidien-3-carboxylic acid in the reaction media. The desired anti-Mannich products were obtained in good to excellent yields (up to 93%), excellent diastereoselectivities (up to 99:1 dr), and good to high enantioselectivities (up to 99% ee). |
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Keywords: | Enantioselective Modularly designed organocatalyst Aldehyde Ketone |
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