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Divergent total synthesis of penaresidin B and its straight side chain analogue |
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| Authors: | Tomoya Fujiwara Kazuki Hashimoto Masanori Umeda Saki Murayama Yuki Ohno Bo Liu Hisanori Nambu Takayuki Yakura |
| Affiliation: | Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan |
| Abstract: | The divergent synthesis of penaresidin B and its straight side chain analogue was accomplished by constructing an azetidine ring via SN2 type cyclization of protected 2,3-syn-3,4-syn-4-amino-1,3-dihydroxyhept-6-en-2-yl mesylate and late-stage introduction of an alkyl side chain via olefin cross-metathesis of 4-allylazetidine with readily available terminal alkenes. This synthetic route would be useful to synthesize penaresidin side chain analogues. |
| Keywords: | Analogue Azetidine Olefin cross-metathesis reaction Penaresidin Corresponding author. |
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