Pyridone alkaloids from the scale-insect pathogenic fungus Hypocrella discoidea BCC 71382 |
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| Authors: | Masahiko Isaka Rachada Haritakun Suchada Mongkolsamrit Sumalee Supothina Tao Feng Ji-Kai Liu |
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| Affiliation: | 1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China |
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| Abstract: | Hypocrellutins A–C (1–3), 2- and 4-pyridone alkaloids, were isolated from cultures of the scale-insect pathogenic fungus Hypocrella discoidea BCC 71382. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of hypocrellutin B (2) was determined by ECD calculation. Their plausibly biosynthetic pathways are proposed. All isolated compounds were inactive in the antifungal, antimalarial, antitubercular, and cytotoxic activity assays. |
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| Keywords: | Insect pathogenic fungi Pyridones |
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