Radical-mediated difunctionalization of unactivated alkenes through distal migration of functional groups

Radical-mediated controllable difunctionalization of alkenes provides a powerful tool for the manipulation of olefins and has become a hot topic recently. In general, however, the scope of alkene is largely restricted to the activated alkenes. The development of a general strategy for the functionalization of unactivated alkenes is desired, yet remains challenging. In this review, we have summarized the recent advances in the strategy of intramolecularly distal migration of functional groups which has been efficiently applied in the radical-mediated difunctionalization of unactivated alkenes. A portfolio of functionalities including aryl, cyano, heteroaryl, imino, carbonyl, alkynyl, and alkenyl groups showcase the migratory aptitude.