Development of one-pot benzylic amination reactions of azine N-oxides |
| |
| Authors: | Menek?e Liman Yunus Emre Türkmen |
| |
| Institution: | 1. Department of Chemistry, Faculty of Science, Bilkent University, Ankara 06800, Turkey;2. UNAM—National Nanotechnology Research Center and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara 06800, Turkey |
| |
| Abstract: | An efficient one-pot synthetic methodology has been developed for the benzylic amination reactions of methyl-substituted azine N-oxides that operate under mild conditions. The reaction was found to tolerate quinoline and isoquinoline N-oxides with electron donating and withdrawing substituents as the electrophilic reaction partners as well as a broad range of nucleophilic primary, secondary and aromatic amines, affording the benzylic amination products in up to 82% yield. |
| |
| Keywords: | Benzylic amination One-pot synthesis Heteroaromatic compounds Amines |
| 本文献已被 ScienceDirect 等数据库收录！ |
