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Direct arylation of tertiary amines via aryne intermediates using diaryliodonium salts |
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| Authors: | Zhiang Zhang Xunshen Wu Jianwei Han Wenjun Wu Limin Wang |
| Affiliation: | 1. Key Laboratory for Advanced Materials, Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China;2. Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, PR China |
| Abstract: | With a strategy by using diaryliodonium salts as the precursors of benzynes, direct N-arylation of tertiary amines with diaryliodonium salts was reported. Thus, the desired aromatic tertiary amines with a wide range of substituents were synthesized in moderate to excellent yields of 55–91%. |
| Keywords: | Diaryliodonium salts Benzyne Arylation Aromatic tertiary amines |
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