Mannich Reaction of Indole with Cyclic Imines in Water |
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| Authors: | Liang-Hui Xie Jie Cheng Zi-Wei Luo Gui Lu |
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| Affiliation: | Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China |
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| Abstract: | An efficient MsOH promoted direct Mannich reaction of indoles with α-nonsubstituted aliphatic cyclic imines has been developed. The reactions were performed in water and the obtained piperidin-2-yl-indoles act as a useful precursor for the synthesis of various alkaloid-like derivatives. |
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| Keywords: | Mannich reaction Brønsted acids Aliphatic cyclic imines Water Indole |
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