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Synthesis of luminescent 2,3-diphenylmaleimide-labelled peptide nucleic acid oligomers |
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| Authors: | Prasanna Ramani Silvia Cauteruccio Emanuela Licandro Clara Baldoli |
| Institution: | 1. Dhanvanthri Lab, Department of Sciences, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, India;2. Dipartimento di Chimica, Università degli Studi di Milano, via C. Golgi 19, I-20133 Milano, Italy;3. Istituto di Scienze e Tecnologie Molecolari, C.N.R., via C. Golgi 19, I-20133 Milano, Italy |
| Abstract: | A lys-GTAGATCACT-lys peptide nucleic acid (PNA) decamer labelled with the luminescent 2,3-diphenyl maleimido (DPM) group on the ε-position of the terminal lysine residue was prepared through an automated solid phase synthesis. Fluorescence emission of the DPM-labelled PNA thus obtained was found to be significant and promising for the potential application in DNA recognition. |
| Keywords: | Peptide nucleic acids Solid phase synthesis Amino acids Maleimides Luminescence |
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