|
|||||
|
|
N-3 alkylation of uracils with unprotected amino alcohols using the Mitsunobu reaction |
|
| Authors: | Guillaume Lafitte Audrey Beillard Sandrine Chambon Catherine Soulet Laurence Dumais Grégoire Mouis Jean-François Fournier Laurence Clary Claire Bouix-Peter Loic Tomas Craig S Harris |
| Institution: | Nestlé Skin Health R&D, 2400 Route de Colles, 06410 Biot, France |
| Abstract: | During our search for novel CGRP antagonists, we had great difficulty in accessing one of our key motifs. Herein, we communicate how we solved the problem by an unprecedented Mitsunobu alkylation using unprotected amino alcohols. |
| Keywords: | Unprotected amino alcohols CGRP (Calcitonin gene-related peptide) |
| 本文献已被 ScienceDirect 等数据库收录！ | |