首页 | 本学科首页   官方微博 | 高级检索  
     


Understanding the tetrazole ring cleavage reaction with hydrazines: Structural determination and mechanistic insight
Authors:Olga Ya. Shyyka  Nazariy T. Pokhodylo  Yurii I. Slyvka  Evgeny A. Goreshnik  Mykola D. Obushak
Affiliation:1. Department of Organic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya St. 6, Lviv 79005, Ukraine;2. Department of Inorganic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya St. 6, Lviv 79005, Ukraine;3. Department of Inorganic Chemistry and Technology, Jo?ef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia
Abstract:A distinction in the behaviour of several hydrazines as N-nucleophiles in the recently developed one-pot method for pyrimidine core annulation via 1H-tetrazole ring cleavage was examined. The product structures, 2,3-diamino- or hydrazino derivatives of thieno[3,2-d]pyrimidin-4(3H)-ones, thieno[2,3-d]pyrimidin-4(3H)-ones and [1]benzofuro[3,2-d]pyrimidin-4(3H)-one, were elucidated based on NMR and single crystal X-ray analysis.
Keywords:Hydrazines  Regioselectivity
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号