Design,synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives |
| |
| Authors: | Ming-Ming Li Fan Xia Cheng-Ji Li Gang Xu Hong-Bo Qin |
| |
| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China |
| |
| Abstract: | Tanshinones were used as starting material to synthesize a small library of nitrogen heterocyclic derivatives featured with oxazole, imidazole, and pyrazine ring between C-11/C-12 by simple methods. Except for salviamine A and isosalviamine A, 22 new derivatives were synthesized. Their structures were confirmed by spectroscopic analysis. Moreover, 11 derivatives exhibited moderate cytotoxic activities against five human cancer lines in vitro. |
| |
| Keywords: | Tanshinones Heterocyclic compounds Cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
