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Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols |
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| Authors: | Farzana Kouser Vijay Kumar Sharma Masood Rizvi Shaista Sultan Neha Chalotra Vivek K Gupta Utpal Nandi Bhahwal Ali Shah |
| Institution: | 1. Academy of Scientific and Innovative Research and Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, India;2. Department of Chemistry, University of Kashmir, Srinagar, India;3. Department of Physics, University of Jammu, Jammu, India |
| Abstract: | A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides. |
| Keywords: | 4-Phenylbut-3-enoic acid Thiophenol Photoredox γ-Lactone γ-Ketoamide |
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