Cyclotriphosphazene,a scaffold for 19F MRI contrast agents |
| |
| Authors: | Emel Önal Cheng Zhang Derya Davarcı Ümit İşci Guillaume Pilet Andrew K. Whittaker Fabienne Dumoulin |
| |
| Affiliation: | 1. Chemistry Department, Gebze Technical University, Gebze, 41400 Kocaeli, Turkey;2. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld 4072, Australia;3. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Brisbane, Qld 4072, Australia;4. Université de Lyon, Laboratoire des Multimatériaux et Interfaces (LMI), UMR 5615 CNRS-Université Claude Bernard Lyon 1, France |
| |
| Abstract: | A cyclotriphosphazene substituted with six 3,5-bis(trifluoromethyl) benzyloxy units was designed as a novel 19F MRI contrast agent. The resulting molecule has 36 magnetically equivalent fluorine atoms and exhibited suitable MRI properties with high imaging sensitivity, confirming the proof-of-concept as a convenient scaffold for the production of new 19F MRI contrasts agents. |
| |
| Keywords: | Cyclotriphosphazene Contrast agent |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
