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Synthesis of phosphorus analogs of TSAO-T |
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| Authors: | Marina Moura Solen Josse Denis Postel |
| Institution: | 1. Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (UMR7378), 10 rue Baudelocque, 80039, Amiens, France;2. Institut de Chimie de Picardie (FRE 3085), UFR des Sciences-UPJV, 33, rue Saint Leu, 80039, Amiens, Cedex 1, France |
| Abstract: | Phosphorus Analogs of TSAO bearing an oxaphospholene ring instead of an oxathiole dioxide ring at C-3′ position were prepared. Strategy developed previously on saccharidic moiety was used with introduction of an electron withdrawing α group neighboring the phosphorus atom. Biological evaluation on both HIV-1 and HCV showed that these compounds have no activity. |
| Keywords: | Nucleoside TSAO-T Oxaphospholene |
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