Chiral NHC ligands bearing a pyridine moiety in copper-catalyzed addition of diethylzinc to nitroalkenes |
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| Authors: | Takahiro Soeta Yuichi Hatanaka Tomohiro Ishizaka Yutaka Ukaji |
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| Affiliation: | Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan |
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| Abstract: | Chiral N-heterocyclic carbenes, derived from amino acids containing a pyridine ring, are effective ligands in the enantioselective copper-catalyzed addition of diethylzinc to β-nitroalkenes, which provides access to chiral nitroalkanes. The advantages of this process include high yields, broad and complementary substrate scope, and good to high enantioselectivities. |
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| Keywords: | N-Heterocyclic carbene Catalytic asymmetric Michael addition Nitroalkene |
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