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Tandem Prins cyclization for the synthesis of 1,8-dioxa-3-azaspiro[4.5]dec-2-ene derivatives |
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| Authors: | L Madhava Reddy V Veerabadra Reddy V Satteyyanaidu JK Lakshmi Ch Krishna Reddy BV Subba Reddy |
| Institution: | 1. Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Centre for Nuclear Magnetic Resonance, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;3. Department of Chemistry, Osmania University, Hyderabad 500 007, India |
| Abstract: | A tandem Prins strategy has been developed for the synthesis of 1,8-dioxa 3-azaspiro4.5]dec-2-ene derivatives using 5?mol% Cu(OTf)2 in dichloromethane at 0?°C under mild reaction conditions in short reaction times. This method provides the products in good yields with a diverse substitution pattern. |
| Keywords: | Aldehydes Bifunctional substrate Cascade reactions Spiro-tetrahydropyrans |
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