Halogenated cladosporols produced by the sodium halide-supplemented fermentation of the plant-associated fungus Cladosporium sp. TMPU1621 |
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| Authors: | Hiroyuki Yamazaki Akiho Yagi Masanari Akaishi Ryota Kirikoshi Ohgi Takahashi Tatsuki Abe Satomi Chiba Kenta Takahashi Natsuki Iwakura Michio Namikoshi Ryuji Uchida |
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| Affiliation: | 1. Department of Natural Product Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan;2. Department of Pharmaceutical Physical Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan |
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| Abstract: | A new cladosporol derivative, 2-chloro-cladosporol D (6), was isolated together with known cladosporol (1), cladosporols B–D (2–4), and cladosporol F (5) from the culture broth of plant-associated Cladosporium sp. TMPU1621. The structure of 6 was elucidated from spectroscopic analyses including NMR and MS data. The productivity of 6 increased in 3% NaCl-supplemented medium; therefore, fermentation of the producing fungus TMPU1621 with 3% NaBr was investigated, leading to the induced production of a new halogenated cladosporol, 2-bromo-cladosporol D (7). Compound 2 showed the lowest MIC values of 3.13 and 12.5?μg/mL against two MRSA strains, ATCC43300 and ATCC700698, respectively. |
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| Keywords: | Cladosporol Sodium halide Plant-associated fungus Corresponding authors. |
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