A highly selective coumarin-based chemosensor for the sequential detection of Fe3+ and pyrophosphate and its application in living cell imaging |
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| Authors: | Wei Wang Jian Wu Qinglei Liu Yan Gao Huimin Liu Bing Zhao |
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| Institution: | 1. School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China;2. China Department of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China;3. Chemistry and Chemical Engineering Institute, Qiqihar University, Qiqihar 161006, China |
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| Abstract: | A new chemosensor based on coumarin FB has been designed and synthesized for the detection of Fe3+ and PPi. FB displayed a high affinity to Fe3+ in the presence of other competing cations. The resulting FB-Fe3+ complex displayed highly sensitivity to PPi via Fe3+ displacement approach. The Fe3+ and PPi recognition processes is rapid and reversible, the detection limits of FB to Fe3+ and FB-Fe3+ complex to PPi were estimated to be 8.73?×?10?8?M and 1.25?×?10?8?M, respectively. The good biocompatibility of FB enables the investigation of fluorescent response for Fe3+ and PPi in living cells by confocal microscope. A B3LYP/6-31G(d,p) basis set was employed for optimization of FB and FB-Fe3+ complex. |
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| Keywords: | Coumarin Chemosensor Iron PPi Bioimaging |
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