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Copper-catalyzed oxidative synthesis of 2-oxo-acetamidines from one-pot three-component reaction of aryl methyl ketones,secondary amines and anilines
Authors:Leema Dutta  Pulak J. Bhuyan
Affiliation:Applied Organic Chemistry Group, CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India
Abstract:Some novel 2-oxo-acetamidines were synthesized via one-pot three-component reaction of acetophenones, secondary amines and anilines in presence of CuI as catalyst. The reaction involved in a oxidation process of C (sp3)/>H bonds of acetophenones in presence of air followed by aminations, and products were obtained in good to excellent yields (70–82%) in simple work-up procedure.</td>
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Keywords:Acetophenones  Amines  2-oxo-acetamidines  Copper iodide
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