Synthesis of oxindoles via Cu-mediated reactions between N-phenylacrylamides and ethyl 2-bromo-2-methylpropionate |
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Authors: | Da Liu Shaobo Zhuang Xiang Chen Lin Yu Yongqi Yu Liang Hu Ze Tan |
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Institution: | State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China |
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Abstract: | A novel way of synthesizing alkylated oxindoles via Cu-mediated atom transfer radical addition reaction between N-phenylacrylamides and ethyl 2-bromo-2-methylpropionate has been described. It was found that the use of N,N,N′,N′-1,1,2,2,-tetramethylethylenediamine as ligand was important for achieving good yields. Additionally, the use of DMSO as solvent and running the reaction at 130?°C were also crucial. In some cases, the product can be further brominated when the reaction temperature was raised to 150?°C. |
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Keywords: | Cu-mediated Oxindole Atom-transfer radical addition Cyclization Corresponding author |
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