Enantioselective palladium-catalyzed addition of malonates to 3,3-difluoropropenes |
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Authors: | Myriam Drouin Jean-François Paquin |
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Institution: | CCVC, PROTEO, Département de chimie, 1045 avenue de la Médecine, Université Laval, Québec, QC, G1V 0A6, Canada |
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Abstract: | Monofluoroalkenes bearing a malonate unit at the β position can be synthesized by the enantioselective addition of diesters to 3,3-difluoropropenes. The difference in reactivity regarding the geometry and the substituents of the alkene of the 3,3-difluoropropenes, as well as the alkyl groups of the malonates, was studied and limitations were identified. The reaction was also performed with different 3,3-difluoropropenes. Further synthetic transformations of a newly functionalized monofluoroalkene were also accomplished. |
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Keywords: | Asymmetric synthesis Palladium catalysis Monofluoroalkene 3 3-Difluoropropene Organofluorine chemistry |
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