Chemical constituents of the lichen Usnea baileyi (Stirt.) Zahlbr |
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| Authors: | Kieu Van Nguyen Thuc-Huy Duong Kim Phi Phung Nguyen Ek Sangvichien Piyanuch Wonganan Warinthorn Chavasiri |
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| Institution: | 1. Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand;2. Department of Chemistry, Ho Chi Minh City University of Education, 280 An Duong Vuong Street, District 5, 748342 Ho Chi Minh City, Viet Nam;3. Department of Organic Chemistry, University of Science, National University – Ho Chi Minh City, 227 Nguyen Van Cu Str., Dist. 5, Ho Chi Minh City 748355, Viet Nam;4. Lichen Research Unit and Lichen Herbarium, Department of Biology, Faculty of Science, Ramkamhaeng University, Bangkapi, Bangkok 10240, Thailand;5. Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand |
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| Abstract: | Investigation of the chemical constituents of the lichen Usnea baileyi (Stirt.) Zahlbr led to the isolation of a new dimeric xanthone, bailexanthone (1), and a novel depsidone, bailesidone (2), along with twenty-five known metabolites (3–27). Their structures were established by means of extensive spectroscopic analysis and comparison with data reported in the literatures. Compound 1 derives from secalonic acid scaffold with C-8/8′ reduction and compound 2 represents the first example of menegazziaic acid derivative with an unprecedented B-ring moiety. Two new compounds 1–2 were evaluated for their cytotoxic activities against A549 (human lung carcinoma) and HT29 (human colorectal adenocarcinoma) cell lines. All of them showed weak or no activity against two cell lines. |
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| Keywords: | Lichen Depsidones Dimeric xanthone Cytotoxicity |
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