A facile one-pot synthesis of 2-o-cyanoaryl oxazole derivatives mediated by CuCN |
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| Authors: | Senbao Fan Tao Tong Liting Fang Jingyi Wu Erfei Li Honglan Kang Xin Lv Xiaoxia Wang |
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| Affiliation: | 1. Department of Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, People’s Republic of China;2. School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan 523808, People’s Republic of China |
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| Abstract: | A convenient, inexpensive and effective approach to the synthesis of 2-o-cyanoaryl oxazole derivatives has been developed. Generally, the copper-mediated cyclization/coupling reactions afforded corresponding 2-cyanoaryl oxazoles and oxazolines in moderate to excellent yields. The functionalized oxazole derivatives may be useful in biological chemistry and medicinal science. Our investigation indicates that the formation of the oxazole ring might favor the C | |
| Keywords: | One-pot 2-Cyanoaryl oxazole Copper Cyclization Coupling |
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