One-pot synthesis of 3-(furan-2-yl)-4-hydroxy-2H-chromen-2-ones using K10 montmorillonite clay as heterogeneous catalyst |
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| Authors: | Jin Zhang Wenhao Xue Pei Wang Tao Wang Yong Liang Zunting Zhang |
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| Institution: | 1. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi''an, 710119, People''s Republic of China;2. Department of Environmental and Chemical Engineering, Xi’an Polytechnic University, Xi’an, 710048, People’s Republic of China |
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| Abstract: | A facile and efficient one-pot synthesis of 3-(furan-2-yl)-4-hydroxy-2H-chromen-2-ones was developed. The reaction of ethyl 3-(2-hydroxyphenyl)-3-oxopropanoates and 2,5-dimethoxy-2,5-dihydrofuran were performed in presence of K10 Montmorillonite Clay heterogeneous catalyst under the solvent-free condition at 80?°C for 1?h, and followed by further converted to 3-(furan-2-yl)-4-hydroxy-2H-chromen-2-ones via refluxing in the alkaline EtOH solution for 0.5?h. The demonstrate method not only avoided the usage of any expensive transition-metals, but also eliminated the tedious intermediate purification. Moreover, due to the wide functional group tolerance, it could be applied to various substrates and gave product in good to excellent yields. |
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| Keywords: | Coumarin K10 Montmorillonite clay Solvent-free Transition-metals |
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