Caldorin,a new polyketide from the marine cyanobacterium Caldora penicillata |
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| Authors: | Ikuma Shiota Arihiro Iwasaki Shimpei Sumimoto Hiroshi Tomoda Kiyotake Suenaga |
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| Institution: | 1. Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan;2. Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan |
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| Abstract: | A new polyketide with a cis-fused decalin ring scaffold, caldorin, was isolated from the marine cyanobacterium Caldora penicillata. The gross structure and relative configuration were elucidated by spectroscopic analyses. We also clarified that caldorin is a weak SOAT inhibitor and moderate osteoblast differentiation inhibitor. On the other hand, caldorin did not exhibit cytotoxicity against either HeLa or HL60 cells. |
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| Keywords: | Polyketide Marine cyanobacteria Natural products isolation |
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