Recent development of vinylogous Mukaiyama aldol reactions |
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| Authors: | Seijiro Hosokawa |
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| Institution: | Department of Applied Chemistry, Faculty of Advanced Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan |
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| Abstract: | The vinylogous Mukaiyama aldol reaction (VMAR) is a powerful tool of polyketide synthesis, which constructs a large size structure by simultaneous introduction of the stereogenic center(s) and the α,β-unsaturated carbonyl group. A variety of stereocontrolled VMARs have been developed and applied to natural product synthesis. This review is focused on recent development of the vinylogous Mukaiyama aldol reaction using s-trans silyl dienolates. |
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| Keywords: | Vinylogous Mukaiyama aldol reaction Polyketide Stereoselective synthesis Silyl dienolate Natural product synthesis |
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