Disilylation of N-(2-Halophenyl)-2-phenylacrylamides with hexamethyldisilane via trapping the spirocyclic palladacycles |
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| Authors: | Genhua Xiao Liang Chen Guobo Deng Jianbing Liu Yun Liang |
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| Institution: | National & Local Joint Engineering Laboratory for New Petro-Chemical Materials and Fine Utilization of Resources, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Key Laboratory of the Assembly and Application of Organic Functional Molecules, Hunan Normal University, Changsha, Hunan 410081, China |
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| Abstract: | The palladium-catalyzed disilylation of the spirocyclic palladacycles with hexamethylaisilane has been realized. The key spirocyclic palladacycles are generated from N-(2-haloaryl)-2-arylacrylamide via intramolecular Heck reaction and followed remote C-H activation. A range of 3-((trimethylsilyl)methyl)-3-(2-(trimethylsilyl)phenyl)indolin-2-ones are obtained in good to excellent yields from readily available starting material under mild conditions. |
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| Keywords: | Spirocyclic palladacycles Disilylation Hexamethyldisilane Domino reaction |
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