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Synthesis of functionalized benzothiadiazine 1,1-dioxide derivatives via intramolecular CH activation reactions of trichloroacetamidine and benzenesulfonyl chloride
Authors:Manijeh Nematpour  Elham Rezaee  Mehdi Jahani  Sayyed Abbas Tabatabai
Institution:1. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Chemistry, Sharif University of Technology, Tehran, Iran
Abstract:The synthesis of functionalized benzothiadiazine 1,1-dioxide derivatives was achieved through a novel three-component intramolecular C/>H activation reaction of trichloroacetonitrile, benzenesulfonyl chloride, and various primary amines. This reaction was performed in the presence of catalytic copper(I) and l-proline as the ligand in tetrahydrofuran at room temperature.</td>
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Keywords:Copper-catalyzed  Benzothiadiazine 1  1-dioxide  Benzenesulfonyl chloride  Trichloroacetonitrile  Primary amine
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