Morita-Baylis-Hillman enal-based triple cascade strategy for anti-selective synthesis of highly functionalized tetrahydropyridines using iminium-enamine catalysis |
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| Authors: | Vijai K Rai Fooleswar Verma Mansingh Satnami Manorama Singh Ankita Rai |
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| Institution: | 1. Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495 009, India;2. School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110 029, India |
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| Abstract: | A novel and efficient three-component coupling strategy for stereoselective synthesis of highly substituted tetrahydropyridines (THP) is reported in high yield (83–94%) with excellent diastereoselectivity (95–99%) in favor of anti-isomer. The reaction proceeds via sequential iminium-iminium-enamine mediated formation of three consecutive C | |
| Keywords: | Multicomponent reactions Iminium–enamine Tetrahydropyridine Aldimines |
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