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Two novel iridoid derivatives isolated from Phlomis likiangensis
Authors:Xiao-Hui Li  Li-He Lu  Xu-Hong Li  Yun-Biao Li  Yuan-Chang Duan  De-Huan Fu  Shuang-Xi Mei  Tao Cui  Jing-Kun Wang  Zhao-Yun Zhu
Affiliation:1. Yunnan Institute of Materia Medica, Kunming 650111, China;2. Innovation and R&D Center, Yunnan Bai Yao Group, Kunming 650111, China;3. Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming 650111, China
Abstract:The extract of the aerial and underground parts of Phlomis likiangensis afforded two new iridoid derivatives, namely as phloloside H (1) and phloline (2), along with four known compounds (36), and compound 2 was a novel normonoterpene. Their structures were elucidated on the basis of spectroscopic studies and chemical methods. Six compounds were assayed for cytotoxic, antibacterial and antioxidative activities, but were either inactive or very weakly active.
Keywords:Iridoid  Phloloside H  Phloline  Normonoterpene
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