Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid |
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| Authors: | Yiliang Zhang Li He Lei Shi |
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| Affiliation: | 1. Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen 518055, China;2. MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China |
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| Abstract: | The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities. |
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| Keywords: | Asymmetric catalysis Chiral phosphoric acid Hydrogenolysis Hantzsch ester |
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