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Transition-metal-free synthesis of aromatic amines via the reaction of benzynes with isocyanates
Authors:Jeong Hoon Seo  Haye Min Ko
Affiliation:Department of Bio-Nano Chemistry, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea
Abstract:An unexpected reaction between benzynes and isocyanates to generate aromatic amines has been developed under transition-metal-free conditions. The in situ prepared anions formed through cleavage of the N/>C bond in isocyanates, reacted with aryne precursors to afford various aniline derivatives in moderate to excellent yield and tolerated various substituents on the <em>o</em>-silyl aryl triflate and the isocyanate.</td>
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Keywords:Aniline derivatives  Transition-metal-free  Benzynes  Isocyanates  Fluoride
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