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Blennolide derivatives from the soil-derived fungus Trichoderma asperellum PSU-PSF14 |
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| Authors: | Athip Maha Patima Phainuphong Vatcharin Rukachaisirikul Saowanit Saithong Souwalak Phongpaichit Sarinya Hadsadee Siriporn Jungsuttiwong Sita Preedanon Jariya Sakayaroj |
| Institution: | 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand;4. National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand;5. School of Science, Walailak University, Thasala, Nakhonsithammarat 80161, Thailand |
| Abstract: | Three new blennolide derivatives, blennolides L-N (1–3), together with five known metabolites were isolated from the soil-derived fungus Trichoderma asperellum PSU-PSF14. Their structures were determined by analysis of spectroscopic data. Their relative configurations were determined by analysis of NOEDIFF data and confirmed by X-ray crystallography for compound 1 whereas the absolute configurations were established by means of experimental and calculated TDDFT ECD data. Compound 1 displayed antifungal activity against Cryptococcus neoformans ATCC90112 and ATCC90113 flucytosine-resistant with the MIC values of 128 and 64?μg/mL, respectively, and was inactive against noncancerous Vero cell lines. |
| Keywords: | Soil-derived fungus Blennolide derivatives Antifungal activity Cytotoxic activity |
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