Cytotoxic cytochalasans from Aspergillus flavipes PJ03-11 by OSMAC method |
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| Authors: | Yingying Si Mingxu Tang Shuang Lin Gang Chen Qingmei Feng Yubo Wang Huiming Hua Jiao Bai Haifeng Wang Yuehu Pei |
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| Institution: | 1. School of Traditional Chinese Materia Media, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China;3. School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China |
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| Abstract: | Two new cytochalasans flavichalasine N (1), flavichalasine O (2), together with six known cytochalasans (3–8), were isolated from Aspergillus flavipes PJ03-11 through the application of OSMAC (one strain many compounds) strategy. Flavichalasine O (2) represented the first example of cytochalasans possessing a nitrogen-oxygen heterocycle at the macrocyclic ring part. Their structures were established on the base of extensive spectroscopic analysis. Compounds 1–4 exhibited significant cytotoxic activities against three human cancer cell lines (THP1, HL-60 and PC3) with IC50 values ranging from 3.00 to 15.10?μM. |
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| Keywords: | Cytochalasans Cytotoxic activity OSMAC |
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