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Copper-mediated Chan-Evans-Lam N-arylation of 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol-2-one derivatives
Authors:Basmah Almohaywi  George Iskander  Tsz Tin Yu  Mohan Bhadbhade  David StC Black  Naresh Kumar
Institution:1. School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia;2. School of Pharmacy, King Khalid University, Abha, Saudi Arabia;3. Solid State & Elemental Analysis Unit, Mark Wainwright Analytical Centre, Division of Research, UNSW Australia, NSW 2052, Australia
Abstract:A simple and efficient procedure for the synthesis of N-aryl 5-methylene-4-aryl-1,5-dihydro-2H-pyrrol-2-one derivatives has been developed through copper-mediated C/>N bond formation. The synthetic protocol allows for versatile and robust C<img style=
Keywords:Chan-Evans-Lam coupling reaction  Pyrrole-2-one  Quorum sensing
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