Synthesis of <Emphasis Type="Italic">N</Emphasis>-vinylpyrrolidone copolymers with 2-aminoethyl methacrylate as drug carriers |
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| Authors: | M V Solovskii M S Borisenko A Yu Ershov N V Zakharova E B Tarabukina |
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| Institution: | 1.Institute of Macromolecular Compounds,Russian Academy of Sciences,St. Petersburg,Russia |
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| Abstract: | Radical copolymerization of N-vinylpyrrolidone and 2-aminoethyl methacrylate hydrochloride has been studied. Molecular and hydrodynamic characteristics of the resulting copolymers have been determined, and their structure has been confirmed. Conditions favoring conversion of these copolymers into copolymers of N-vinylpyrrolidone with 2-aminoethyl methacrylate of different composition have been elucidated. The suitability of the prepared copolymers as polymeric carriers of monofluoroquinolone ofloxacin has been demonstrated. |
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