Two new polyketides from Hawaiian endophytic fungus Pestalotiopsis sp. FT172 |
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| Authors: | Chunshun Li Ariel M. Sarotti Wesley Yoshida Shugeng Cao |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, HI 96720, United States;2. Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States;3. Instituto de Química Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Argentina;4. Chemistry Department, University of Hawaii at Manoa, 2545 The Mall, Honolulu, HI 96822, United States |
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| Abstract: | Two new polyketides, pestalotiotones A (1) and B (2) were isolated from the cultured broth of Pestalotiopsis sp. FT172. The structures of compounds 1 and 2 were determined by analysis of HRMS and NMR spectroscopic data. The absolute configurations of compound 1 were assigned by Mosher reaction, J-based configuration analysis, and DP4 NMR calculations. Both compounds were tested against cancer cell lines, pathogenic fungi and bacteria. |
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| Keywords: | Endophytic fungi Hawaii Pestalotiopsis FT172 NMR Mosher reaction |
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