Diterpenoids from the gum resin of Boswellia carterii and their biological activities |
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| Authors: | Jinqian Yu Yanling Geng Hongwei Zhao Xiao Wang |
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| Affiliation: | 1. Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), China;2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China |
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| Abstract: | Seven new diterpenoids, classified as three cembrane-type diterpenoids boscartins I-K (1–3) and four prenylaromadendrane-type diterpenoids boscartols K-N (4–7), respectively, along with nine known diterpenoids, were isolated from the gum resin of Boswellia carterii. Their structure elucidations were achieved by spectroscopic examination. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production and antiproliferative activity against MCF-7 human breast cancer cell in vitro. 4 and 5 exhibited potent inhibitory effects on NO production (IC50 of 2.22 and 1.10?μM, respectively), with 11 showing moderate inhibition (IC50 of 8.63?μM), and 12 and 15 demonstrated moderate antiproliferative effects against MCF-7?cell (IC50 of 9.5, and 6.3?μM, respectively). |
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| Keywords: | Cembrane-type diterpenoid Prenylaromadendrane-type diterpenoid Anti-inflammatory Antiproliferative |
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