Synthesis of 5-(Arylamino)-1-benzyluracils |
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| Authors: | M S Novikov A A Ozerov |
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| Institution: | (1) Research Institute of Pharmacology, Volgograd State Medicinal University, Volgograd, 400131, Russia |
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| Abstract: | The synthesis of novel 5-(phenylamino)-, 5-(benzylamino)-, and 5-(phenethylamino) derivatives of 1-benzyluracil-containing
different substituents in the aromatic nucleus has been carried out. Using the Hilbert-Johnson reaction it was found that
N(1)-monosubstitution can be achieved via alkylation of trimethylsilyl derivatives of 5-(arylamino)uracils using benzyl bromide.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 887–892, June, 2005. |
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| Keywords: | 5-(arylamino)-1-benzyluracil 2 4-bis(trimethylsilyloxy)pyrimidine 5-bromouracil N(1)-alkylation C(5)-amination |
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